Osteomyelitis is a bone infection caused by bacteria or other germs.


Bone infection is most often caused by bacteria, but it can also be caused by fungi or other germs.

In children, the long bones of the arms or legs are most often involved. In adults, the feet, spine bones (vertebrae), and hips (pelvis) are most commonly affected.

Risk factors are:

People who have had their spleen removed are also at higher risk for osteomyelitis.


Other symptoms that may occur with this disease:

Exams and Tests

A physical exam shows bone tenderness and possibly swelling and redness.

Tests may include:


The goal of treatment is to get rid of the infection and reduce damage to the bone and surrounding tissues.

Antibiotics are given to destroy the bacteria causing the infection.

Surgery may be needed to remove dead bone tissue if you have an infection that does not go away.

Infection that occurs after joint replacement may need surgery to remove the replaced joint and infected tissue around the area. A new prosthesis may be implanted in the same operation. More often, doctors wait until the infection has gone away.

If you have diabetes, it will need to be well controlled. If there are problems with blood supply to the infected area, such as the foot, surgery to improve blood flow may be needed to treat the infection.

Outlook (Prognosis)

With treatment, the outcome for acute osteomyelitis is usually good.

The outlook is worse for those with long-term (chronic) osteomyelitis. Symptoms may come and go for years, even with surgery. Amputation may be needed, especially in those with diabetes or poor blood circulation.

The outlook for those with an infection of the prosthesis depends, in part, on:

When to Contact a Medical Professional

Call your health care provider if:


Matteson EL, Osmon DR. Infections of bursae, joints, and bones. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 280.

Berbari BF, Steckelberg JM, Osmon Dr. Osteomyelitis. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2009:chap 103.

Review Date: 5/30/2012
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School, Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
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