Hypopituitarism is a condition in which the pituitary gland does not produce normal amounts of some or all of its hormones.

Alternative Names

Pituitary insufficiency


The pituitary gland is a small structure that is located just below the brain. It is attached by a stalk to the hypothalamus, the area of the brain that controls its function.

The hormones released by the pituitary gland (and their functions) are:

Pituitary gland

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Pituitary gland

In hypopituitarism, there is a lack of one or more pituitary hormones. Lack of the hormone leads to loss of function in the gland or organ that it controls. For example, no TSH leads to loss of function in the thyroid gland.

Hypopituitarism may be caused by:

Occasionally, hypopituitarism is due to uncommon immune system or metabolic diseases, such as:

Hypopituitarism is also a rare complication after pregnancy, a condition called Sheehan's syndrome.


Note: Symptoms may develop slowly and may vary greatly, depending upon:

Other symptoms that may occur with this disease:

Exams and Tests

To diagnose hypopituitarism, there must be low hormone levels due to a problem with the pituitary gland. The diagnosis must also rule out diseases of the organ that is affected by this hormone.

Tests include:

Levels of a pituitary hormone may be high in the bloodstream if you have a pituitary tumor that is producing too much of that hormone. The tumor may crush other cells of the pituitary, leading to low levels of other hormones.


If hypopituitarism is caused by a tumor, you may need surgery to remove the tumor, with or without radiation therapy. 

You will need lifelong hormone therapy to replace hormones that are no longer made by organs under the control of the pituitary gland. These may include:

Drugs are also available to treat related infertility in men and women.

Outlook (Prognosis)

Hypopituitarism is usually permanent and requires lifelong treatment. However, you can expect a normal life span.

Possible Complications

Side effects of drug therapy can develop. In severe illness, failing to take extra corticosteroids can be life-threatening.

When to Contact a Medical Professional

Call your health care provider if you develop symptoms of hypopituitarism.


In most cases, the disorder is not preventable. Awareness of risk may allow early diagnosis and treatment.


Melmed S, Kleinberg D, Ho K. Pituitary physiology and diagnostic evaluation. In: Kronenberg H, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 8.

Review Date: 12/11/2011
Reviewed By: Nancy J. Rennert, MD, Chief of Endocrinology & Diabetes, Norwalk Hospital, Associate Clinical Professor of Medicine, Yale University School of Medicine, New Haven, CT. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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